Active Biotech » Tasquinimod

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Here we investigated whether pharmacological inhibition of S100A9 with tasquinimod inhibits MM progression. The following is a listing of clinical trials for patients with multiple myeloma who have received one to two prior lines of therapy. Phase 1 Study of Tasquinimod Alone and in Combination With Standard Therapy for Relapsed or Refractory Myeloma Tasquinimod is developed as a new immunomodulatory treatment for multiple myeloma. Tasquinimod has previously been studied as an anti-cancer agent in patients with solid cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer. The tolerability of tasquinimod is well-characterized based on these previous experiences.

Patents in key markets have been granted, providing protection for the use of tasquinimod in malignant A population of myeloid-derived suppressor cells (MDSCs), abundantly producing the pro-inflammatory S100A9 protein, promotes myeloma progression. Tasquinimod (TASQ) is an investigational drug that targets MDSCs via the S100A9 protein. 2017-04-19 This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). TASQUINIMOD Tasquinimod –A new drug class which is complementary to current multiple myeloma therapies 6 Tasquinimod restores immune function and decreases vascularization of the tumor microenvironment Immunomodulators (IMiDs) Cereblon Proteasomeinhibitor (PI) Proteasome Monoclonalantibody CD38 and SLAM7 Alkylatingagents DNA alkylgroups Drugclass Target 2020-08-12 Tasquinimod (ABR-215050, Active Biotech/IPSEN) is a quinoline-3-carboxamide derivative that binds to S100A9 and blocks its interaction with receptors TLR4, RAGE, and CD147. Here we investigated whether pharmacological inhibition of S100A9 with tasquinimod inhibits MM progression.

Active Biotech » Tasquinimod

Tasquinimod has previously been studied as an anti-cancer agent in patients with solid cancers, including a phase 3 randomized trial in patients with metastatic prostate cancer. The tolerability of tasquinimod is well-characterized based on these previous experiences. This study is the first study of tasquinimod, an inhibitor of S100A9, in patients with multiple myeloma.

Active Biotech announces first patient dosed in phase 1b/2a study of

What is multiple myeloma? Multiple myeloma is a rare type of cancer that affects bone marrow and alters your blood’s plasma cells. Plasma cells ON THIS PAGE: You will find out more about body changes and other things that can signal a problem that may need medical care. Use the menu to see other pages.

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This trial will establish a maximum tolerated dose and optimal schedule for administration of tasquinimod in patients with multiple myeloma and then investigate the maximum tolerated dose of tasquinimod in combination with a standard myeloma regimen of ixazomib, lenalidomide, and dexamethasone (IRd). The introduction of proteasome inhibitors in to the multiple myeloma healing armamentarium has resulted in a dramatic improvement in scientific outcomes (1C5).

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5 Jan 2021 Tasquinimod, is in clinical phase Ib/IIa for treatment of multiple myeloma. Laquinimod is advancing to phase II for treatment of non-infectious 2017年4月18日 Active Biotech公司近日宣布，美国食品和药物管理局（FDA）已授予实验性抗癌药 tasquinimod治疗多发性骨髓瘤（multiple myeloma，MM）的 3 aug 2020 För både tasquinimod som monoterapi och kombinationen av med givna responskriterier från International Myeloma Working Group. Studien 8 Dec 2014 1Laboratory of Hematology and Immunology, Myeloma Center Quinoline-3- carboxamides or Q compounds (e.g., Tasquinimod) were able to Early treatment for high-risk smouldering myeloma: has the time come? Heinz Ludwig. Full-Text Tasquinimod treatment for prostate cancer.